The researchers note that, “acupuncture reduces drug self-administration and dopamine release in the nucleus accumbens (NAc), a brain structure implicated in stress-induced reinstatement of drug-seeking behavior.” The NAc is an area of the brain important to motor function, rewards and emotions. Dopamine, glucocorticoids, GABA and serotonin play important roles in the NAc.
Using footshock stress to re-stimulate cocaine addiction behavior, researchers applied acupuncture to acupoint HT7 (Shenmen) for one minute following footshock stress to a control group and an acupuncture group. For the control group, footshock stress reinstated cocaine addiction behaviors. In the acupuncture group, there was an 86.5 percent inhibition rate of cocaine addiction. As a result of biochemical measurements taken during the study, the researchers note that the mechanism by which acupuncture prevents cocaine addiction relapse may be due to the ability of acupuncture to regulate “neuronal activation in the NAc shell.”
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